Human health
Each patient's biology, made measurable.
We discover and validate molecular signatures — from a blood draw or a biopsy — that reveal each patient's underlying biology. A foundation for precision medicine, serving pharma companies, biotechs and diagnostics players.
The observation
One diagnosis, different biologies.
Behind a single clinical label, distinct biological mechanisms coexist. Two patients carrying the same diagnosis may belong to different biologies — and thus to different treatments.
Making these differences measurable — through a blood draw or a biopsy — opens the way to better-targeted clinical trials, better-oriented treatments and finer patient monitoring.
Applications
From clinical trials to patient monitoring.
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Clinical-trial stratification and enrichment
Select patients carrying the biological mechanism a molecule targets, and change the economics of a clinical program.
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Patient endotyping
Identify biologically homogeneous subgroups within a single disease, to guide care decisions.
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Reading treatment response
Objectify the biological effect of an intervention, beyond clinical criteria alone.
Our approach
Rigour before promise.
A signature: a frozen gene panel, extracted from the noise of tens of thousands of measurements.
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Multi-gene molecular panels
Frozen, traceable expression signatures, measurable on standard laboratory technologies from a blood or tissue sample.
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Independent external validation
Every signature is replicated on cohorts independent from discovery before being proposed to a partner.
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Specificity mapping
We systematically delineate the perimeter of a signal by challenging it against neighbouring diseases and conditions: knowing what a signature does not detect matters as much as knowing what it does.
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Pre-specified confounder controls
Demographics, cell composition, routine inflammation markers: a signature is only valuable if it adds information beyond what already exists.
Multi-omics
Layers of data, one readout.
Genomics, transcriptomics, proteomics, microbiome: each layer captures one facet of the biological system. Our signatures emerge from crossing these layers into molecular networks, from which we extract the most informative nodes.
Portfolio
A first program, more to come.
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Neuroinflammation & dementia
Our most advanced program: a blood signature of innate immune activation associated with dementia, aimed in particular at patient selection for therapies targeting neuroinflammation. Validated on independent external cohorts.
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Transplantation
A molecular readout of graft-rejection mechanisms on biopsy, replicated across several independent external cohorts — a demonstration of the platform's reach beyond blood and neurology.
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Areas under exploration
The same discovery and validation methodology applies to other therapeutic areas — immunology, inflammation and beyond.
Each program is protected by an intellectual-property strategy; detailed characteristics are shared under confidentiality.
Partnering
Work with us.
We offer collaborations as pilot studies on biobanked samples, co-development programs and licensing agreements. Analyses are run by TerraBiome on coded data, in compliance with regulatory and confidentiality requirements.
TerraBiome signatures are research tools intended for study and development purposes. They are not diagnostic devices for routine medical use.